Cycling cell protocols –

Revised 10 Sep /17

Here we introduce the resources and thought process used to develop an intervention strategy to confront an existing cancer burden.  We also see that chronic elevated levels of reactive oxygen species (ROS) make many cancer conditions worse, yet mainstream tumor treatment modalities are rooted in the acute and overwhelming generation of ROS.  At first glance perplexing paradoxes with hyped compounds show each can act as either a pro-oxidant, or an antioxidant, perceived opposites in the spectrum of maintaining ROS levels – dose is a huge factor.

In the midst of these observations, patterns are unveiled from subtle alterations in metabolite concentrations.  Clear and unambiguous phrases emerge from these studies like, ‘X’ “preferentially kill’s cancer cells”, or “acts synergistically with ‘Y’ to target apoptosis”, or “causes massive ROS accumulation”, or “short-term exposures measured in hours and days proved beneficial … whereas long-term exposures led to uncontrolled growth”; from these captivating phrases, we uncovered a few novel approaches.

When visualizing these types of approaches, it is important to 1st note what they are not; they do not include the analogy of a silver bullet being an all-powerful intervention, nor do they include random concoctions of touted anti-cancer foods or supplements.  Yet an arsenal of slingshots, trip wires, and arrows exist, that when combined in certain combinations act synergistically, and in theory, when teamed in subsequent coordinated assaults are envisioned to overwhelm and decimate cancers of any type.     A coordinated assault entails deliberate and rapid cycling between the upper and lower safe limits of critical parameters for all normal cells, while exploiting vulnerabilities in known cancer pathways; a proof-of-concept trial is underway @ McGill.  While the very nature of life entails commotion in our cells, we are learning that all of the commotion is controlled to a great extent.  Our efforts suggest there is a theoretical opportunity to deliver a disruptive and preferentially lethal environment for cancer, yet remain benign to normal cells.  This is the foundation for this approach; on top of that, properly controlled, this type of approach would be void of toxicity and orders of magnitude less expensive than the ‘gold standard of care’ presently in use.  …and this comparison was originally written well before the ~ $ 250k price tag for some 2017 immunotherapy regimes

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  • Rapid cycling of cells
    • physiologic changes occur in as little as minutes or hours
    • benefits from dietary interventions apparent within days
    • incorporates alternating between deficient and surplus status of key molecules, or rapid (but controlled) changes in physiologic conditions like pH.